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pentobarbital will increase the degree or result of ivosidenib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Coadministration of ivosidenib with powerful CYP3A4 inducers lessened ivosidenib plasma concentrations.pentobarbital will minimize the level or result of dasatinib by affecting hepatic/intes

Phenobarbital lowers the plasma levels of dicumarol (title previously utilized: bishydroxycoumarin) and results in a lessen in anticoagulant action as measured through the prothrombin time. Barbiturates can induce hepatic microsomal enzymes resulting in greater metabolism and lessened anticoagulant reaction of oral anticoagulants (e.In patients wit